Bioviva
https://longevity.vc/ – Laura Deming – https://vimeo.com/159009830
https://forever-healthy.org/en/
http://www.libellagenetherapeutics.com/
https://www.sierrasci.com/ – http://defytimer.com/defytime-shop-telomeres-bill-andrews-anti-aging-supplements/
http://youthereum.io/ – article
FIRST GENE THERAPY SUCCESSFUL AGAINST HUMAN AGING
Unity biotechnology, Elysium health,..
About Deep Knowledge Life Sciences (DKLS), BGRF and Avi Roy, SENS and Aubrey de Grey
TAME. Metmorfin
http://www.lifeextension.com/Vitamins-Supplements/item02119/Ageless-Cell
https://www.elysiumhealth.com/basis. A lot of research points to NAD+-promoters as a promising approach.
Applying AI to discovery and formulation of geroprotectors
https://www.wikiwand.com/en/Senolytic
Can we engineer the end of ageing? - Daisy Robinton - TEDxLondonSalon
Drugs to Extend Life - Nathaniel David, CEO of Unity Biotechnology – Unity biotechnology
http://www.longevityreporter.org/
https://global-longevity-initiative.webflow.io/
David Sinclair: Can Aging Be Reversed?
PREVENT . RESTORE . PRESERVE
Do not go gentle into that good night, Old age should burn and rave at close of day; Rage, rage against the dying of the light. — Dylan Thomas
NLA, CASMI, Oxford and BGRF to develop the Global Healthspan Extension Initiative
two of her own company’s experimental gene therapies:
- one to protect against loss of muscle mass with age,
- another to battle stem cell depletion responsible for diverse age-related diseases and infirmities.
Telomeres are short segments of DNA which cap the ends of every chromosome, acting as ‘buffers’ against wear and tear. They shorten with every cell division, eventually getting too short to protect the chromosome, causing the cell to malfunction and the body to age.
“Current therapeutics offer only marginal benefits for people suffering from diseases of aging. Additionally, lifestyle modification has limited impact for treating these diseases. Advances in biotechnology is the best solution, and if these results are anywhere near accurate, we’ve made history”
Note: this is awesome
It remains to be seen whether the success in leukocytes can expanded to other tissues and organs, and repeated in future patients
Gene therapy to save the world
10 responses to “Hacking Aging” What would you say if I told you that aging happens not because of accumulation of stresses, but rather because of the intrinsic properties of the gene network of the organism? I’m guessing you’d be like: :o .
C-elegans 10-fold lifespan increase paper
Liz talk
.......
- Telomerase gene therapy.
- * To avoid stem cell depletion (as it controls how many times a cell can divide)
- Remethylates genes. As we grow old, more genes are activated, eventually causing cancer. We want to disactivate them
- Muscle mass. Myostatin inhibition, AAV Follistan
- CRISPR - many genes could be targeted.
- Parabiosis. blood borne factors in young blood can rejuvenate old mice. Human trial going on now. Both positive factors from young mouse, and negative factors being cleared
- Senecent cell removal. Liposomal targeting, gene therapy
- Glycation. AGE breakers
- Mitochondria.
Cell therapy and tissue bioprinting_
IPSC/ESCs/Adult stem cells . Ex vivo gene correction
Repurposing of pharmaceuticals in market.
Metmorfin, senolytic drugs.
Gene editing, gene therapy, stem cell therapies
Immunotherapy, targeted cancer approaches. T-cell. Ablation. Modulate allergies!
Monoclonal antibiotics. Non-permanent gene ..
Rapid genomics
Big data crunching.
https://www.youtube.com/watch?v=GoJsr4IwCm4 – https://www.youtube.com/watch?v=C25qzDhGLx8
I think that not supporting anti-ageing technology because of fears such as overpopulation is like not having supported the development of anaesthesia and painkillers in the 18th century from fears of women having more babies, having removed the excruciating pain of childbirth.
Similar stories can be conjured from most radical medical advances.
Such possibilities should not even compare with the immense benefits in the well-being of people, coming from the alleviation of terror and suffering that accompanies them.