See book on diff geom.
Introduction to differentiable manifold – formal definition of differentiable manifold
A differentiable structure is what we need to add to a set in order to do differential Calculus on it. In particular differentiation (derivatives) of functions defined on the set. It is what it's needed to define differentiability of functions in a consistent way. It also allows to do Integration (what do you integrate? Differential forms)
Some common manifolds. The differentiable structure induces a topology (Topology)
Relation between differentiable and topological structures
Locally homeomorphic to Euclidean space
Differentiable manifolds are automatic topological manifolds, as the required local Diffeomorphism to R^n is a homeomorphism.