Prostaglandin PGE2 is a candidate molecule for potentiating regeneration in multiple different tissues. PGE2 is produced by the enzyme activity of cyclooxygenase-1 or cyclooxygenase-2 (COX-1 and COX-2) followed sequentially by that of prostaglandin E synthase. These come from anachidonic acid..

PGE2 augments Wnt signaling (10, 11), a pathway that is involved in the maintenance of several types of tissue stem cells, including hematopoietic and colon stem cells

It promotes Tissue regeneration, and is thus used as a target in Regenerative medicine