Population genetics

cosmos 3rd February 2017 at 12:10pm
Evolution Genetics

Mathematical population genetics

See Evolution

See Wright-Fisher model, Arrival of the frequent, Monomorphic limit (Wright-Fisher model), Polymorphic limit (Wright-Fisher model).

Second Bangalore School on Population Genetics and Evolution

School and Discussion Meeting on Population Genetics and Evolution (video lectures)

Some terms: gene, genotype, allele, (gene) locus, haploid, diploid, homozygote, heterozygote, heterozygosity, monoecious, dioecious, polymorphism,link age, recombination.

https://en.wikipedia.org/wiki/Haplodiploidy

Fixation time

Intuition

Coalescent


Speciation

Separation of genetic populations driven by geographic isolation

Hybrid infertility

Population structure

Single-nucleotide polymorphism used to track movement of human populations

Most of our mutations are the same (and originated in Africa)

Natural selection pressure can cause fast speciation

Genome-wide association studyes: identify which parts of the Genome that influence Disease, for designing drugs, personalized medicine.

STRUCTURE: a model-based approach, using Gibbs sampling method for Bayesian inference


SImple frequency calculation: video


Drug resistance


Computational biology - An evolutionary approach

https://en.wikipedia.org/wiki/Neutral_theory_of_molecular_evolution

Some mathematical models from population genetics course

Mathematical Population Genetics lecture notes

Theoretical evolutionary genetics - Felsenstein (book), pdf

Probability Models for DNA Sequence Evolution

Population Genetics V: Neutral Theory

Wright-Fisher model with some stuff on the coalescent

Random Genetic Drift & Gene Fixation

Some mathematical models from population genetics book

Moran model

Genetic Drift and Effective Population Size

Heterozygosity and the Wright-Fisher model (stackexchange)

Quantitative genomics (MIT) ppt

STOCHASTIC MODELS FOR GENETIC EVOLUTION

Diffusion Process Models in Mathematical Genetics

Short course on statistical population genetics

ON THE PROBABILITY OF FIXATION OF MUTANT GENES IN A POPULATION’

THE AVERAGE NUMBER OF GENERATIONS UNTIL FIXATION OF A MUTANT GENE IN A FINITE POPULATION'

Notes on population genetics and evolution: “Cheat sheet” for review

Intuitive explanation of fixation time

See Probability theory and Stochastic processes

Sampling with and without replacement